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Alzheimer's (Causes (Vascular abnormalities (worse supply of nutrients…
Alzheimer's
Causes
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Vascular abnormalities
- worse supply of nutrients
- worse removal of metabolic by-products --> causes microinfarcts, promotes activation of astrocytes and microglia
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ApoE e4
- increases AB production
- impairs AB clearance
- impairment of mitochondrial functions
Tau protein
could assemble with pathogenic oligomers --> form larger aggregates --> displacing intracellular organelles (also alpha-synuclein)
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Symptoms
- Gradual loss of episodic memory
- Word-finding difficulties
- Getting lost in familiar neighborhoods
Late stage: incoherence, non-verbal, sleep & motor deficits
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Diagnosis
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family history, assessment of cognitive functions
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Non-genetic causes?
- low level of education
- severe head injury
- cerebrovascular disease
- diabetes & obesity
--> DIET, LIFESTYLE, SOCIAL ENGAGEMENT, MENTAL ACTIVITY, ENVIRONMENTAL ENRICHMENT
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