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Hypoxic ishemic encephalophaty (decrease cerebral blood flow (Cerebral…
Hypoxic ishemic encephalophaty
decrease cerebral blood flow
Cerebral
Hypoxemia
decrease
Glucose
decrease ATP due to anearobic metabobic
Na/K Pump failure
Massive depolarization from influx Na
increase intracellular Ca
mitocondrial injury
Generation of Reaction oxygen species
2 more items...
activation of NO
free radical
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activation of
Caspases
Distruption of protein synthesis
activation of
Calpains
fragmentation of cellular DNA
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increase extracellular glutamate
increase activation of AMPA and NMDA receptor
increase intracellular lactate production
Nerve cell and glial cell injury
seziure
Breathing center depression
Bradychypnea
Apnea
HR<60 /min,no tone ,no crying >> PPV = 30 sec. on ETT
Dyspnea
Primary energy failure phase
Secondary energy failure phase
Latent period
Restoration of cerebral blood flow
reperfusion and reoxygenation of blood tissue
oxydative stress
Cellular death
exitotoxicity
inflammation
endothelin,thromboxane A2
permeability
Stimulation Immune system
vascular response
Therapeutic
hypothermia