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Ceftazidime images (Mechanism of action (Pencillin-binding proteins are…
Ceftazidime
Brand name
Fortaz
Tazidime
Indications
Including peritonitis
For peritonitis in patient undergoing peritoneal dialysis
Suitable for the treatment of intra-abdominal infections
Used for treatment of joint and bone infection like osteomyelitis
Used in pseudomonal infection
For lower respiratory tract infections including pneumonia
As well as nosocomial pneumonia
Route of administration
Intravenous
Intramuscular
Storage conditions
Protect from light
Discard unused medication 4 hours after time of opening
Protect from freezing
Store in carton until time of use
Mechanism of action
Pencillin-binding proteins are responsible for several steps
In cell wall production and
Allocated inside the bacterial cell wall
Are found in quantities of several hundred to
By selectively attaching to specific pencillin- binding proteins
Several thousands
Inhibit third and final stage of bacterial cell wall production
Activity of ceftazidime against a particular organism
Depends on their ability to gain access to bind with
Necessary pencillin-binding proteins
Side effects
Mild diarrhoea
Seizures
Abdominal pain
Moderate jaundice
Contraindications
If patients develop diarrhoea treatment should be stopped
Should be given with caution in patients with renal
Use with caution in patients with pencillin hypersensitivity
Failure because the drug is excreted by renal mechanism
