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Polycythaemia Vera (Clinical Presentation (Gout due to increased turnover…
Polycythaemia Vera
Clinical Presentation
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May present with vague symptoms due to hypersensitivity - headaches, itching, tiredness, dizziness
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Treatment
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Venesection - aims to lower PCV and platelet count & removal of 400-500mL of blood weekly to relieve symptoms
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Diagnosis
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Bone marrow biopsy showing prominent erythroid, granulocytic and megakaryocytic proliferation
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Pathophysiology
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Excess proliferation of RBCs, WBC & platelets - raised haematocrit
A clonal stem cell disorder resulting in a malignant proliferation of a clone derived from one pluripotent marrow stem cell
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