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Non-Hodgkin's Lymphoma (Diagnosis (Marrow and node biopsy for…
Non-Hodgkin's Lymphoma
Epidemiology
Generally more varied in terms of presentation, sub-types, treatments and outcomes
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Clinical Presentation
Systemic B symptoms - fever, night sweats, weight loss
Pancocytopenia - anaemia, infection and bleeding (due to reduced platelets) due to marrow involvement
Extranodal disease (25%) - skin (especially T-cell lymphomas) & oropharynx, gut, small bowel, bone, CNS and lungs
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Diagnosis
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CT/MRI of chest, abdomen and pelvis for staging (Ann Arbor)
Lymph node excision or bone marrow biopsy - won't see mirror image nuclei Reed-Sternberg cells or variant cells (popcorn cells)
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Raised lactose dehydrogenase reflects worse prognosis since its a sign of increased cell turnover and thus cell proliferation
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