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Hodgkin's Lymphoma (Diagnosis (Bloods - High ESR or Low Hb (indicate…
Hodgkin's Lymphoma
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Clinical Presentation
A smaller proportion of patients (often YOUNG WOMEN) present with disease localised to the mediastinum with cough due to mediastinal lymphadenopathy
Others present with 'generalised disease' including hepatosplenomegaly and constitutional B symptoms - weight loss, fever, night sweats
Most commonly there is painless cervical lymphadenopathy, commonly described on examination as 'rubbery'
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Diagnosis
Bloods - High ESR or Low Hb (indicate worse prognosis), high serum lactate dehydrogenase
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Lymph node excision or bone marrow biopsy - will see mirror-image nuclei Reed-Sternberg cells or variant cells (popcorn cells)
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CT/MRI of chest, abdomen and pelvis for staging (Ann Arbor)
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Treatment
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Treatment Complications
Radiotherapy
May increase risk of second malignancies - solid tumours especially in the lung, breast etc.
Increase risk of ischaemic heart disease, hypothyroidism, and lung fibrosis due to radiation field
Chemotherapy
Myelosuppression, nausea, alopecia (hair loss) and infection
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