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Salmonella (Enteric Fever (Pathogenesis (Humans are the only Reservoir,…
Salmonella
Enteric Fever
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Generalized infection of the RES and Intestinal Lymphoid tissue accompanied by bacteriemia and sustained fever
Pathogenesis
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Transmitted to mesentric lymph nodes to thoracic duct then blood stream leading to 1st transient bactremia
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re invades the the blood, second heavier bactreimia with onset of fever
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2nd week, salmonella feaces and 25% of patients in urine
symptoms include fever, headache, abdominal pain, and constipation
complications include relapse, bowel perforation and heamorrhage from bowel ulceration.
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Treatment
fluroquinolones(ciprofloxacin), and cephalosporins. in chronic carriers of s. typhi use ampicillin and ciprofloxacin
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