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Pre-Eclampsia (Development (Epidemiology:
Family history/genetic:
1st…
Pre-Eclampsia
Development
Epidemiology:
Family history/genetic:
1st baby, 2nd baby, Second pregnancy with 2 different partners, subsequent pregnancy after multiparous, mental health issues, obesity, chronic hypertension
Genetic susceptibility:
Failure of trophoblast invasion - shallow invasion results in poor placental development
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The Ripple effect
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Ischaemia:
under perfusion of the placenta results in the placenta attaching to the uterine wall thus causing uteroplacental ischaemia. toxins released from the placenta in the blood.
These substance will then cause endothelial dysfunction
Endothelial dysfunction:
Vasoconstriction
Platelet aggregation
Microthrombiformation and increased capillary permeability.
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Testing
Urine analysis (proteinuria, other kidney problems)
Blood tests (liver function, kidney function, and to measure for potential low platelet count)
Lung exam (pulmonary oedema)
Fetal ultrasound
Nonstress test and/or biophysical profile
CTG – A method of measuring both fetal heart rate and uterine contractions.
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Subgroups:
- Mild-moderate: BP >140/90, proteinuria >300mg in 24 hour collection sample
- Severe: BP >170/110 on at least two occasions over several hours