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Role of Resting Membrane Potential in Circadian Rhythm (What are…
Role of Resting Membrane Potential in
Circadian Rhythm
IPRG Cell in Retina Detection of Light
References
Martha H, Joseph S, & Fred W. Overview of Circadian Rhythms 2001;25(2):89-93.
Vasu S, Huaiyu G, Vijay K. S, Diane K & Todd C. Circadian- and Light-Dependent Regulation of Resting Membrane Potential and Spontaneous Action Potential Firing of Drosophila Circadian Pacemaker Neurons. J Neurophysiol 2008;99(2): 976–988
What are circadian rhythm?
Physical, mental, and behavioral changes that follow a daily cycle.
they respond primarily to light and darkness in an organism's environment.
Examples: Sleeping at night and being awake during the day.
Suprachiasmatic Nucleus Receives Impulse
Absence of Light
Influx of K+
Hyperpolarize at 6-10mV
Induces secretion of melatonin
Inhibit/reduce action potential of dorsal root ganglion
Preparing the body to fall sleep
Decrease body temperature
Muscle contraction will reduce
Reduce heart rate
RMP 50-55mV
Threshold 45-mV
Presence of Light
Influx of Na+
Depolarization at -30mV
Inhibition of endocrine functions of Pineal gland
No secretion of Melatonin
