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Nephrotic Syndrome (Focal Segmental Glomerulosclerosis (usually idiopathic…

- - - - cytokine mediated damage
- - - - mesangial expansion
      - GBM thickening
      - increased permeability
      - hyaline arteriolosclerosis
  - - - increased GFR
      - glomerular hypertrophy
      - glomerular scarring
      - glomerular HTN
      - microalbuminuria
  - - - Kimmelstiel-Wilson lesions
- - - - M protein virulence factor
  - - - "starry sky"/"lumpy bumpy"
- - - - linear IF
  - - - PR3-ANCA/c-ANCA
    - - MPO-ANCA/p-ANCA
    - - MPO-ANCA/p-ANCA
      - granulomas, eosionphilia, asthma
- - - - RBC casts
      - follows mucosal infections
- - - - IgG Ab
        
        stabilizes C3 convertase
        
        persistent complement activation
        
        decreased C3 levels
    - - dense deposit disease
  - - - LM: tram track appearance