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Treatment of peptic ulceration and inflammatory bowel disease (Proton Pump…

- - - - Approx. 50% bioavailability, half life 2-2.5hrs, renal excreation
      - Better tolerated than cimetidine
    - - 60% bioavailability, half life 2 hours, renal excretion
  - - - Can interact with androgen receptors
        
        Gynaecomastia in men
        
        Decreased sexual function
      - Inhibits cytochrome P450
        
        Slows the metabolism (and potentiates action) of range of drugs e.g. oral anticoagulants and tricyclics
      - Confusion in the elderly
- - - - Salts of magnesium and aluminium
  - - - Helps bloating and flatuence
- - - - Offer full-dose PPI or H2RA therapy for 8 weeks
        
        If H. pylori is present, subsequently offer eradication therapy