Please enable JavaScript.
Coggle requires JavaScript to display documents.
Gut motility disorders and constipation (Laxatives (Stimulant laxatives (E…
Gut motility disorders and constipation
Laxatives
Stimulant laxatives
E.g. Senna
Faecal softeners
E.g. Docusate
Osmotic laxatives
E.g. Lactulose
Peripheral opoid-receptor antagonists
E.g. methynaltrexone bromide
Bulk-forming laxatives
E.g. Ispaghula husk
Approaches to treatment of acute diarrhoea
Maintenance of fluid and electrolyte balance
Antimotility drugs
E.g. loperamide (imodium
Antispasmodics
Examples
Hyoscine butylbromide (buscopan)
Mebeverine
Occasionally antibacterial agent is indicated
E.g. systemic bacterial infection, campylobacter enteritis, shigellosis and salmonellosis
Approaches to the treatment of chronic diarrhoea
Antimotility drugs
E.g. loperamide (imodium
Adsorbents
Kaolin, light
Bulk forming drugs
Useful in controlling diarrhoea associated with diverticular disease
E.g. ispaghula
Treatment of gallstones
The use of lap chole and modern endoscopic techniques has limited the place of medication to treat gallstones
Ursodeoxycholic acid is still used to dissolve gallstones (mainly if mild symptoms and not amenable to other treatment)
Treatment of biliary colic and acute cholecysitis
Pain
Opioids given parenterally
Morphine
Pethidine
NSAIDs
Diclofenac given by suppository
Parenteral/ rectal route are chosen as overcomes difficulties in absorption caused by vomiting
Cholestyramine
Anion-exchange resin
Forms an insoluble complex with bile acids in the intestine
Relieves pruritis associated with partial biliary obstruction and primary biliary cirrhosis
Can also be used in some instances of diarrhoea e.g. Crohn's related, and in hypercholesterolaemia