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Inflammatory Carcinoma of the Breast (Symptoms (enlarged breast, usually…
Inflammatory Carcinoma of the Breast
Definitions
Inflammatory breast cancer is rare but the most aggressive and fatal form of breast cancer
blockage of lymphatic channels in their dermis of the breast by tumor emboli which result in clinic symptoms mimicking inflammation
divided into two categories: primary or secondary IBC
most rare aggressive and fatal entity of breast cancer
Etiology
In most cases, cancer cells spread (metastasize) from the lymph vessels.
When metastasizes occurs, the condition affects the skin, potentially other organs, and becomes more difficult to treat.
Results when cancer cells block lymph vessels-- small, hollow tubes which allow lymph fluid to drain out of the breast.
Symptoms
enlarged breast
usually no palpable lump
swelling
tenderness
redness varying from blush pink to red hot
warmth
discoloration
rash
nipple discharge
changes in shape or texture
Risk factors
Gender: Females have a higher likelihood of developing the condition.
Race: African American women are at a greater risk than Caucasian women.
Body Weight: More common in individuals with a higher BMI
Age: More common in younger aged individuals.
Genetics: Presence of the BRCA 1 or BRCA 2 gene.
Family history of IBC
Women who experience pregnancy at a younger age.
Treatment
beginning with chemotherapy to localize cancer:
neoadjuvant chemo
mastectomy:
entire breast is removed
radiation therapy of chest wall
hormone treatment
Tamoxifen,
Aromatase inhibitor
axillary disection
5-fluorouracil, doxorubicin, and cyclophosphamide
Ways to diagnose
biopsy
-hole punch, or surgical
often misdiagnosed as a
skin infection
leads to a
stage 3 or 4
diagnosis
Imaging modalities
CT
- computed tomography
MRI
- magnetic resonance imaging
most accurate way of detecting and monitoring
high frequency
sonography
PET
(positron emission tomography)
Citations
Febery, A & Bennett, I (2019). Sonographic features of Inflammatory conditions of the breast.
Australasian Journal or Ultrasound in Medicine, 22, 165-173.
https://doi.org/10.1002/ajum.12170
Papalouka, V., Gilbert, F. (2018). Inflammatory breast cancer-importance of breast imaging. European Journal of Surgical Oncology. Volume 44, Issue 8, Pages 1135-1138. Retrieved from
http://www.sciencedirect.com/science/article/pii/S0748798318310588
Van Uden, D., Van Laarhoven, H., Westenberg, A., De Wilt, J., Blanken-Peeters, C. (2015). Inflammatory breast cancer: An overview. Volume 93, Issue 2, Pages 116-126. Retrieved from
https://www-sciencedirect-com.libproxy.misericordia.edu/science/article/pii/S1040842814001541
Brzezinska, M., & Dixon, J. M. (2018). Inflammatory breast cancer: no longer an absolute contraindication for breast conservation surgery following good response to neoadjuvant therapy. Gland surgery, 7(6), 520–524. doi:10.21037/gs.2018.08.04
Ueno, N. T., & Fink, T. (2014). Inflammatory breast cancer: an update. (pp. 11-15) Berlin: Springer.
https://books.google.com/books?id=CvDwJdwZMa4C&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
Presentation
Our group will be presenting our project through a powerpoint with a voiceover. Bailey will be presenting what the condition is, including a definition and the signs/symptoms associated to the condition. Kelsi will be presenting the imaging modalities and procedures used to diagnose the conditions and treatments. Alyssa will be presenting the etiology of the condition and the risk factors associated.
Sonographic Appearances
stromal coarsening
diffuse increased breast density
skin thickening
microcalcifications
inc echogenic breast parancema
enlarged lymph node will have uniform thickening of cortex and preservation of hilum
irregular/ lobulated lymph nodes
hyperechoic or heterogeneous lymph nodes