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THE CHEMICAL HISTORY BEHIND PARACETOMOL (paracetomol ((a common…

- - - - The signals of carbohydrates are in the range 60–100 ppm and alkyl carbons of polyethylene glycol or stearate within 20–40 ppm. In the 13C MAS spectrum of a tablet,6 aromatic carbons of paracetamol molecule C2 and C6 as well as C3 and C5 show separate resonances, due to the frozen conformation of NH (CO)CH3 substituent at C1 and the OH group at C4
      - form of paracetamol was prepared20 from the melt of the commercially available monoclinic form. A 13C CP/MAS solid-state NMR spectrum of the monoclinic
      - form and a spectrum of a mixture of forms were obtained. Subtraction of the spectrum of the monoclinic form from that of the mixture yielded a spectrum of the orthorhombic form. These spectra show distinct differences, especially for the resonances arising from the aromatic carbons, i.e., between 115 and 125 ppm. The 13C CP/MAS solid-state NMR spectrum of commercial paracetamol is in agreement with that reported previously, but it is more resolved. The resonances arising from those carbons bound to the nitrogen (132.5 and 169.3 ppm) are broader or appear as asymmetric doublets due to 13C–14N dipole–dipole interactions which are not completely averaged out by MAS.
      - https://www.sciencedirect.com/topics/chemistry/paracetamol
- - - - low fever with nausea, stomach pain, and loss of appetite;
      - dark urine, clay-colored stools; or
      - jaundice (yellowing of the skin or eyes).
      - https://www.drugs.com/paracetamol.html
    - - Bloody or black, tarry stools
      - bloody or cloudy urine
      - fever with or without chills (not present before treatment and not caused by the condition being treated)
      - pain in the lower back and/or side (severe and/or sharp)
      - pinpoint red spots on the skin
      - skin rash, hives, or itching
      - sore throat (not present before treatment and not caused by the condition being treated)
      - sores, ulcers, or white spots on the lips or in the mouth
      - sudden decrease in the amount of urine
      - unusual bleeding or bruising
      - unusual tiredness or weakness
      - yellow eyes or skin