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Neuroscience 1 (passive properties (capacitance (defines times constant,…
Neuroscience 1
passive properties
resistance
membrane
decreases w channels
axial
decreases w diameter
capacitance
decreases with thickness
increases with polarity of material
defines times constant
current
change in Voltage along membrae causes axial flow
lambda = propagation lenght
increases with R-membrane
decreases with R-axial
how far till volt decays to 36%
usually is mm
so chance in voltage in body of neunron doesent effectively changes voltage at synapse
resting potencial
Erns't equation
equilibrium V of single [ion] with passive channeles
forces
eletrostatical
diffusiviness
much weaker
0.001% of ions diffuse
GHB equation
Equilibrium voltage of [ions] wheighted by permeability
steady state rather than equilibrium
depends on NaK pump
consumes 70% of energy
action potetntial
Na voltage-gated channels
more likely to open when E raises to ~ -50mV
inactivate when too positive
diff Na Ernst and resting potential
influx of Na
raise of Em
positive feedback
K voltage-gated channels
slower than Na channels
opens when Na deactivate
resets Em
signal propagation