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Cretinism (Clinical manifestations (Jaundice, pale skin, Floppiness, low…
Cretinism
Clinical manifestations
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Floppiness, low muscle tone
Very little crying, excessive sleep
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Poor feeding, constipation
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Lack of weight gain, stunted growth
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Causes
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Use of medicines that disrupt thyroid hormone production such as anti-thyroid drugs, sulfonamides, or lithium during pregnancy
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Pathophysiology
The pathogenesis of neurologic cretinism is obscure but may be due to severe thyroid hormone deficiency during a critical early phase of central nervous system development in utero.
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