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Gigantism (Clinical Manifestations (Delayed puberty, Irregular menstrual…
Gigantism
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Diagnostic Procedures
Oral glucose tolerance test to see how growth hormone levels change when blood sugar level is increased.
Blood tests – to measure the level of hormones, and sometimes other substances.
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Pathophysiology
Defect in hypothalumas which directs the anterior pituitary gland to release excess amount of growth hormone.
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Overproduction of the Growth hormone, caused by hyperplasia of the anterior pituitary gland, may develop into a tumour.
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Treatment
Pharmacological
Pegvisomant is a recently developed drug that blocks the action of growth hormone in your body, thereby lowering IGF-1 levels.
Dopamine agonists can lower IGF-1 and growth hormone levels in about half of the people treated with them
Octreotide or lanreotide are synthetic forms of the hormone somatostatin and stop the release of growth hormone.
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Radiotherapy
To control growth hormones levels and symptoms, and shrink the tumour.
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