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Glitazones (Thiazolidinediones) (contraindications (contraindicates all…
Glitazones (Thiazolidinediones)
contraindications
contraindicates all the patients with diabetes
Pregnancy
breastfeeding
history of heart failure
do not give with insulin.
route of administration
administered orally.
indications
it is effective in the treatment of type 2 diabetes.
mechanism of action
they target the peroxisome proliferator- activated receptor-y, nuclear hormone receptor. ligands for PPRy regulate adipocyte production and secretion of fatty as well as glucose metabolism.
they reduce tissue resistance to insulin.
side effects
hepato-toxicity
weight gain
increase in plasma LDL
shork
vomiting
drug interaction
statins
calcium channel blockers
erythromycin
effect on kidney
liver toxicity although not many cases reported.