Glitazones (Thiazolidinediones) (contraindications (contraindicates all…
contraindicates all the patients with diabetes
history of heart failure
do not give with insulin.
route of administration
it is effective in the treatment of type 2 diabetes.
mechanism of action
they target the peroxisome proliferator- activated receptor-y, nuclear hormone receptor. ligands for PPRy regulate adipocyte production and secretion of fatty as well as glucose metabolism.
they reduce tissue resistance to insulin.
increase in plasma LDL
calcium channel blockers
effect on kidney
liver toxicity although not many cases reported.