Please enable JavaScript.
Coggle requires JavaScript to display documents.
Sickle Cell Anaemia (Epidemiology (1 in 4 chance of disease, 50% chance of…
Sickle Cell Anaemia
Epidemiology
-
-
-
-
Commonest in Africans but also in India, Middle East and southern Europe
Clinical Presentation
Pulmonary hypertension - mean pulmonary artery pressure greater than 25mmHg by right heart catheterisation
-
-
Many problems occur in growth & development, bones, cardiac, neurological, liver, renal, eye and pregnancy
Vaso-occlusive crises - acute pain in the hands and feet owing to vast-occlusion of the small vessels and avascular necrosis of the bone marrow in children
-
Treatment
-
-
Precipitating factors such as infection, cold and dehydration should be avoided or treated quickly
-
Pathophysiology
The flexibility of the cells is decreased and they become rigid and take up their characteristic sickle appearance
-
-
-