GLP-1 Agonists
Mechanism of action
Side effects
Contraindicatios
Drugs in this class
Direct stimulation of the GLP-1 receptor
Nausea
Increased risk of pancreatitis and possibly pancreatic cancer.
Preexisting, symptomatic gastro intestinal motility disorders.
Lyxumia (lixisenatide)- Taken once daily
Patient with family history of medullary thyroid carcinoma
Trulicity (Dulaglutide)- Taken once weekly
Byetta (Exenatide)- Taken twice daily
Bydureon- Taken once weekly
Diarrhea
weakness with dizziness
Picture
patients with multiple neoplasia syndrome type 2
Decreases glucagon concentrations
Improves insulin sensitivity
Indications
Normally prescribed for patients who have not been able to control their condition with tablet medication.
effect on the kidneys
lowering glucose
exert beneficial effects on traditional risk factors for CKD.
Dosage
Maintenance: 30 - 50 mg once a week
Max: 50 mg once a week
Starting: 30 mg once a week
May administer without regard to food
If dose is missed, patient should administer ASAP within 3 days of missed dose.