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Thiazolidinediones (Adverse Effects (Congestive Heart Failure, Edema and,…
Thiazolidinediones
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mechanism of action
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a group of nuclear receptors, specific for PPARγ (PPAR-gamma, PPARG)
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Administration
are taken orally once a day, with or without food
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Dosing for treatment
Pioglitazone: Initial 15 to 30 mg PO with a meal once a day; may increase the dose by 15 mg with careful monitoring to 45 mg once a day.The maximum dose is 45 mg.
Rosiglitazone: Initial 4 mg PO once a day. If inadequate response after 8 to 12 weeks, may increase the dose to 8 mg PO once a day or divided 12 hourly(4 mg twice a day).
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definition
Are a class of medicines that may be used for the treatment of type 2 diabetes and they are a type of oral hypoglycemic
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