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Insulin degludec -tresiba (Side effects (Swelling, Rash, Lipodystrophy,…
Insulin degludec -tresiba
Is a long-acting basal human insulin analog for subcutaneous injectiom
Indications
Treatment for patients with diabetes mellitus
Side effects
Swelling
Rash
Lipodystrophy
Injection site reactions
Itching
Weight gain
Hypoglycemia
Headache
Upper respiratory tract infection
Runny or stuffy nose
Sinusitis
Contraindications
Geriatric, visual impairment
Breast-feeding
Hypoglycemia
Tobacco smoking
Hypokalemia
Pregnancy
Storage
Protect from light
Refrigerate between 2°to 8°C
Do not freeze
Store in original container
Store opened product at room temperature
Mechanism of action
It forms multi hexamers in subcutaneous tissues
To delay absorption from depot
Also highly bound to serum albumin
nursing consideration
use caution when mixing two types insulin
store insulin in a cool place away from sunlight
do not give insulin injection concentrated IV ,severe anaphylatic shock may occur
monitor urine or serum glucose levels to determine effectiveness of drugs
give regular insulin IV or IMI in severe ketoacidacis or diabetic coma
keep life support equipment and glucose readily available to deal with ketoacidasis
rotating injection site regularly to decrease incidence of lipodostrophy
definition