DPP-4-Inhibitors

Mechanism of action

Side effects

Indications

Effects on the kidneys

Picture

Headache

sore throat

nasopharyngitis

Skin reactions

Drugs in this class

Onglyza (Saxagliptin)

Galvus (Vildagliptin)

Januvia (Sitagliptin)

Block the action of DPP-4, an enzyme which destroys a group of gastrointestinal hormones called incretins.

May be used as a second or third line medication for people with type 2 diabetes after prescribing metformin and sulphonylureas.

May be prescribed as an alternative to thiazolidinedione medication.

Contraindications

History of serious hypersensitivity reaction to DPP-4 inhibitors.

Dosage

dpp4

Nephroprotective effects beyond the reduced renal risk conferred by glycemic control.

DPP-4 inhibitors have beneficial renal effects mainly by reducing the risk of development or progression of albuminuria compared with placebo or other antidiabetic agents.

ALOGLIPTIN: 25mg once daily, may take without regard to food.

SAXAGLIPTIN : Take 2.5mg to 5mg maximum is 5mg, take without regard to food.

LINAGLIPTIN: 5mg once daily, take with or without meals.