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DPP-4-Inhibitors (Side effects (Headache, sore throat, nasopharyngitis,…
DPP-4-Inhibitors
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Dosage
ALOGLIPTIN: 25mg once daily, may take without regard to food.
SAXAGLIPTIN : Take 2.5mg to 5mg maximum is 5mg, take without regard to food.
LINAGLIPTIN: 5mg once daily, take with or without meals.
Indications
May be used as a second or third line medication for people with type 2 diabetes after prescribing metformin and sulphonylureas.
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Effects on the kidneys
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DPP-4 inhibitors have beneficial renal effects mainly by reducing the risk of development or progression of albuminuria compared with placebo or other antidiabetic agents.
Mechanism of action
Block the action of DPP-4, an enzyme which destroys a group of gastrointestinal hormones called incretins.
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