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Alpha-glucosidase inhibitors (Adverse effects (Abdominal pain, Diarrhea,…
Alpha-glucosidase inhibitors
Mechanism of action
Able to slow down digestion of complex carbohydrates in the intestine, which is another route to decreasing the postprandial glucose excursion.
Dosage
Strengths: 25 mg, 50 mg, and 100 mg
25 mg taken three times per day for adults
Adverse effects
Abdominal pain
Diarrhea
Flatulence
Mild itching or skin rash
Weight gain
Contraindications
Patients with hypersensitivity to the drug
Patients with diabetic cirrhosis
Patients with congested heart failure with liver failure
Colon ulceration
Drugs in this class
Miglitol
Voglibose
Acarbose
Indications
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
eEfect on the kidneys
AGIs-induced liver injuries
