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THIAZOLIDINEDIONES GROUP (Contraindications (Liver disease, History of…
THIAZOLIDINEDIONES GROUP
Mechanism of action
They seem to reduce the tissue resistance to insulin
Increase insulin sensitivity
Definition
Is an anti-diabetic drugs that belong to a group of chemical called glitazones
Examples of thiazolidinediones drugs
Tosiglitazone
Pioglitazone
Clinical use
They control non-insulin dependent diabetic mellitus when combined with other agents.
Adverse effects
Weight gain
Increase in plasma LDC level
Liver toxicity
Contraindications
Liver disease
History of heart failure
Breastfeeding
Do not give with insulin
To pregnant women
Drug interaction
That enzyme also metabolises a number of other durgs like calcium channel blockers
Proglitazon induces an enzyme that is partly responsible for its metabolism.
Side effects
Oedema
Weight gain
Heart failure
Bone fracture
Storage
Store in room temperature
Routes of administration
It is given orally
Indication
To treat type 2 diabetes