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THIAZODIONES eg PIOGLITAZONES (SIDE EFFECTS (heart failure, upper…
THIAZODIONES eg PIOGLITAZONES
DEFINITION
drug indicated as an adjunt to die and exercise
is to improve glycaemia control in type 2 diabetes
SIDE EFFECTS
heart failure
upper respiratory infection
hypoglacaemia
muscle pain
oedema
liver toxicity
headache
weight gain
MECHANISM OF ACTION
exerts its anti-hyperglycaemic effect only in the of endogenous insulin
CONTRA-INDICATIONS
history of heart failure
hypersensitivity
liver disease
diabetic ketoacidosis
breastfeeding
pregnancy
DRUG INTERACTIONS
erythromycin
ciclosporin
calcium channel blockers
statins