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posiglitazones-thiazolidinediones (side effects (liver failure, anaemia,…
posiglitazones-thiazolidinediones
mechanism of action
reduces insulin resistance trough stimulation of PPAR's (peroxisome proliferator-activated receptors)
increases transcription of adipokines
side effects
liver failure
anaemia
heart problems
bone fractures
macular oedema
weight gain
indications
type 2 diabetes
suplement to sulfonylurea or insulin therapy
contra indications
patients with a history of heart failure
type 1 diabetes for treatment of diabetic ketoacidosis
bladder cancer
pregnancy
route of administration
15 mg to 30 mg oral with meals once a day