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SULFONYLUREAS eg GICLAZIDES (SIDE EFFECTS (light headedness, heartburn,…
SULFONYLUREAS eg GICLAZIDES
MECHANISM OF ACTION
it potentiates insulin release and improves insulin dynamics.
thus the insulin is increased
stimulates B-CELLS of islets of Langerhans in the pancreas
pheripheral insulin sensitivity is increased
SIDE EFFECTS
light headedness
heartburn
diarrhea
heartburn
hypoglaceamia
lethargy
nausea
INDICATIONS
when insulin is not an option and diet fails
control of blood sugar in type 2 diabetes
CONTRAINDICATIONS
concurrent use of oral/oromucosal miconazole
concurrent use of alcohol or alcohol containaing treatment
severe hepatic or renal impairement
pregnancy
unstable diabetes
lactation
hypersensitivity
DEFINITION
Anti-diabetic drugs that increase insulin made by the pancreas