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thiazolidinediones rasiglitazone (adverse effects (hypoglycaemia, weight…
thiazolidinediones rasiglitazone
action
increase insulin action
decrease insulin resistance
decrease triglyceride levels
adverse effects
hypoglycaemia
weight gain
oedema
transient anaemia
cardiac failure
LDL -cholesterol increase
dosage
4 mg per day
if not glycaemic response is inadequate after 8-12 weeks ,increase dose to 8 mg per day
contraindication
hepatitis
liver failure
pioglitazone treatment
smoking
hypersensitivity
indications
improve insulin resistance
monotherapy
dual therapy in combination with metformin and sulonylurea
triple therapy combination with metformin an sulonylurea with insulin
route
oral