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METFORMIN metfomin pict (Side effects (Asthenia, Flatulence, Nausea and…
METFORMIN
Mechanism of action
It stimulates the uptake of glucose into muscles
It inhibits gluconeogonis
It reduces glucose absorption from the gastrointestinal tract
Reduce glucose release from the liver
Definition
This is a drug that is prescribed for treating type 2 diabetes
It belongs to a group called bignarides
Clinical use
It is used combined with insulin in patients with insulin dependent diabetic meliitus.
It is used combined with one of sulphonylureas when the patient is not responding.
Adverse effects
Long term use may interfere with vitamin B 12 absorption
It can cause lactic acidosis
Transiet gastrointesinal disturbances
Side effects
Asthenia
Flatulence
Nausea and vomiting
Muscle pain
Decreased appetite
weight loss
Abdominal pain
Upper respiratory tract infection
Weakness
Dosage
Maximum dose is 2550 mg per day
Extended dose is 500 to 1000 mg once a day
Initial dosage for immediate-release is 500 mg orally twice a dayor 850 once a day.
Indications
Prevent blindness
prevent nerve problems
Loss of limbs
Sexual function problems
Prevent blindness
Increase muscle sensitivity
Contraindications
Severe heart failure
Renal impairment
Acute myocardial infaction
Routes of administration
It is given orally
Storage
In a room temperature
Away from sunlight
Tightly closed
Away from moisture
Keep in container
How does Metformin affects kidneys?
That can lead to kidney failure
Can lead to lactic acidosis
Dosage
It is given once or twice a day
It applies to the following strengths; 500 mg, 750 mg, 850mg, 1000 mg, 500 mg/5mL
