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Biguanide-Metformin (side effects (lactic acidosis, anemia, hypoglycemia,…
Biguanide-Metformin
side effects
lactic acidosis
anemia
hypoglycemia
diabetic ketoacidosis
diarrhoea
upper respiratory tract infection
nausea and vomiting
abdominal pain
chills and dizziness
mechanism of action
thereby increases glucose uptake in response to available insulin
thirdly it reduces glucose absorption in the gut
2nd, it sensitizes insulin receptors in target tissues
it does not stimulate insulin release from the pancreas
1st it inhibits glucose production in the liver
lowers blood glucose and improve glucose tolerance in 3 ways
contraindications
liver failure
chronic heart failure
severe renal disease
metabolic acidosis with or without coma
storage
store in a room temperature in a closed container
keep it away from heat
store at 20 to 25 degrees celcius
indications
indicated to patient with type 2 diabetes
used with insulin to improve glycemic control in adult
route of administration
oral take 500 mg twice a day with meals
is the drug of choice of choice for initial therapy in most patient with type 2 diabetes.