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METFORMIN (CARDIOVASCULAR OUTCOME TRIALS, MECHANISM OF ACTION (gut, to…
METFORMIN
CARDIOVASCULAR OUTCOME TRIALS
MECHANISM OF ACTION
gut, to reduce hepatic glucose output
muscle glucose uptake increases
skeletal muscle and the
Targets the liver
GLP-1 level increases
glucose absorption decreases
SIDE EFFECTS
nausea
vomiting
diarrhea
lowers B 12 serum
cramping
Flatulane
NON-GLYCAEMIC BENEFITS
measures of inflammation improve
Coagulation
decreases cancer rate
oxidative stress
lipid profile improvement
HYPOGLYCEMIA
Some patients may show signs
potentiate hypoglycemic effects
Not severe as mono-therapy
of insulin or insulin secretagogues
DOSING AND PRESCRIPTION
RENAL DOSING
WIEGHT
Or modest weight loss
no weight loss-non diabetic
May be neutral
GLYCAEMIC EFFICACY AND INDICATIONS