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Oral diabetes medication (classifications (thiazolidinediones (mechanism…

- - - - rosiglittazone(avandia) 15-45mg per day
      - pioglitazone(actos) 4-8mg per day
    - - increase sensitization of target tissues to insulin
      - they bind to the intracellular perixisome proliferator-activated receceptor-gamma in tissues
      - results in an increased expression of glucose transport-4 receptor
      - it also affects liver and skeletal muscles
      - in the liver glucose uptake increases and insulin levels is decreased
      - uptake of glucose by muscles is increased
    - - cause weight gain
      - fluid retention
    - - they are not administered to patients with stage 4 heart failure
      - they do not increase insulin
- - - - it lowers blood sugar level in people with diabes
      - lowers amount of sugar produced by the liver
      - it increases muscle cells sensitivity to insulin
      - lowers absorption of sugars from intestines
      - lowers sugar level between and after meal
    - - diarrhea
      - lactic acidosis
      - vomiting and flatulence
      - asthenia and decreased vitamin B12 concentration