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SGLT2 inhibitors SGLT PHOTO (Side effects (Mycotic genital yeast infection…
SGLT2 inhibitors
Machanism of Action
Thus gliflozins reduce renal glucose reabsorption
this leads to excess urinary glucose levels
This group inhibits sodium-glucose co-transporter-2
indications
Type 2 Diabetes Mellitus patients
it has benefits for patients with Cardiovarscular disorders
Side effects
Mycotic genital yeast infection
kidney disorder
UTI
Constipation
flue like symptoms
Nasal congestion
Dehydration and hyperhydration
Contraindications
risk for stroke, fracture
Amputation
risk for dehydration and hypotension
bladder cancer & Ketoacidosis
Urinary tract infection patients
Drugs in this class
Invokana (Canagliflozin)
Jardiance (Empagliflozin)
Forxiga (Dapagliflozin)
Dose
Dapagliflozin
eGFR =45-60 ml/min
Contraindicated
eGFR ≥60 ml/min
5 mg or 10 mg
eGFR <45 ml/min
Contraindicated
Empagliflozin
eGFR =45-60 ml/min
proceed with 25 mg but
no therapy intiation
eGFR <45 ml/min
Contraindicated
eGFR ≥60 ml/min
10 mg or 25 mg
Canagliflozin
eGFR =45-60 ml/min
proceed 100 mg but
no therapy initiation
eGFR <45 ml/min
Contraindicated
eGFR ≥60 ml/min
100 mg or 300 mg
