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EFFECTS OF BURNS (RENAL SYSTEM : : (Acute Kidney Injury (Cardiac…
EFFECTS OF BURNS
RENAL SYSTEM : :
Acute Kidney Injury
:Hypervolemia and Abdominal Compartment Syndrome
decreased renal perfusion
results in
release of oxygen free radicals
cause
direct tubular damage
obstructive nephropathy
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disrupt tight junctions
cellular death
ischemia
Cardiac dysfunction
hemodynamic derangements
leads to
cardiodynamic derangements
cardiac infections from the wounded skin
Denatured proteins
Muscle breakdown
which is
Rhabdomyolysis
myoglobin
results in
blockage of renal tubules
blockage of renal tubules
free hemoglobin
release of denatured proteins
Sepsis
Sepsis and septic shock
causes are
multifactorial
DIGESTIVE SYSTEM
caused by
Intestinal barrier dysfunction
bacteria/endotoxcin called dysbiosis
decreased beneficial bacteria
increased dangerous bacteria
cause
rheumatoid arthritis and diabetes (non-related condition)
irritable bowel disease
SEPSIS
lead to
Stress
enhance activies of
hypothalamic-pituitary-adrenal axis and sympathetic nerve system
severe systemic stress responses
increased intestinal permeabilty
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hypoxia/ischemia
causes
extravasation of plasma
hypovolemic shock
ischemia of tissues
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hypoxia of tissues
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proinflammatory cytokines
large amounts of proinflammatory cytokines are released
which are
inteferon gamma (IFN-γ)
tumor necrosis factor-α (TNF-α)
interleukin-1β (IL-1β)
interleukin-6 (IL-6)
leads to
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