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Insulin Therapy (Mechanism of Action (Inhibits hepatic glucose production,…
Insulin Therapy
Mechanism of Action
Inhibits hepatic glucose production
Insulin inhibits lipolysis and proteolysis
By skeletal
muscle and fat
Enhances protein synthesis
Stimulating peripheral glucose uptake
. Indications
Fasting plasma glucose levels >14 mmol/l
Random glucose levels consistently > 16.5 mmol/l
Non-pregnant adults
Presence of persistent ketogenesis, ketoacidosis
Any stage of type 2 diabetes
Contraindications
Surgery
Thyroid disease
Renal impairment
Hepatic disease
Intravenous administration
Side effect
Systemic allergy
Oedema
Lipodystrophy
Local allergy
Storage Condition
Always check the expiration date
Keep at 15-25 degrees for 28 days
Never let your insulin freeze
Keep insulin away from heat & light
Drug name
Long-acting
Glargine
Intermediate-acting
NPH - neutral protamine Hagedorn
Rapid-acting
Aspart
Short-acting
Actrapid
Class
Insulin
Dosage
Basal insulin
10 u