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Acarbose (Contra-indication (cirrhosis, diabetic ketoacidosis,…
Acarbose
Contra-indication
cirrhosis
diabetic ketoacidosis
inflammatory bowel disease
colonic ulceration
partial intestinal obstruction
Adverse effects
severe itching
severe stomach pain
allergic reaction ,which includes hives, difficulty in breathing or swelling
severe constipation
effect in kidneys
they possess high concentration of p-cresol and other proteins fermantation metabolites
patients with chronic kidney disease and haemodialysis are affected
Doses
can increase to 50-100 mg oral 8 hourly at 4 to 8 week interval
initial dose of 25mg orally eight hourly
Mechanism of action
slowing food digestion helps keep blood glucose from rising very high after meals
works by slowing the action of certain chemicals that break down food to release glucose
Group
Alpha glucosidase inhibitors
Indication
used in adults with diabetes type 2