Amylin analog pramlintide
Mechanism of action
Storage
Route of administration
Indications
Contraindications
affects glucose control through several mechanisms
slowed gastric emptying, regulation of postprandial glucagon, and reduction of food intake
Glucagon-like peptide-1 exhibits similar properties as amylin, with the exception of insulin secretory effects.
Side effect
nausea
vomiting
headache
hypoglycemia, if taken alongside insulin
Adverse effect
joint pain,
fatigue,
allergic reaction
dizziness.
Less apetite
adjunctive treatment in patients with type 1 or type 2 diabetes
who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy.
subcutaneously immediately prior to each major meal
≥250 kcal or containing ≥30 grams of carbohydrate
should be at room temperature before injecting
Refrigerate (2°C to 8°C; 36°F to 46°F)
dose should be administered subcutaneously into the abdomen or thigh
poor compliance with current insulin regimen.
poor compliance with prescribed self blood glucose monitoring.
have a HbA1c >9%
recurrent severe hypoglycemia requiring assistance during the past 6 months.