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Urinary and Reproductive Diseases: Lecture 4 (Chlamydial Infection (Life…
Urinary and Reproductive Diseases: Lecture 4
Syphilis
Primary stage s/s
small painless reddened hard lesion at the infected site 10-21 days after
chancre can have serum and infectious spirochetes filled and can occur anywhere
Secondary stage s/s
sore throat, HA, mild fever, malaise, wide spread rash
Latent stage: no symptoms for up to 10 years
tertiary stage
yrs later: dementia, blindness, heart failure, paralysis
can have gummas: rubbery swollen lesions in bones, nervous tissue, and on skin
Pathogen: Treponema pallidum; only lives in humans
makes hyaluronidase to make it easier to get in intracellular space
transmitted through sexual contact or from mom to baby
common among sex workers, homosexuals, and illegal drug use
dx by an antibody test like MHA-TP that uses RBC's that have been artificially coated with antigens
treat: penicillin G is used for all types except tertiary
prevent by safe sex practices; no vaccine
Chlamydial Infection
most common type of infection
s/s: most women have no symptoms, men have painful urination and pus discharge from urethra
can cause epididymis, PID, orchitis, testes inflammation, trachoma, disease of eye in babies.
can cause lymphogranuloma venerum: form genital lesion and bubo, painful inflam lymph node; can rupture causing discharge and sores
Pathogen: chlamydia trachomatic; all strains but one are in humans
Life cycle
only grow in a vesicle
elementary bodies are the infective form
reticulate bodies are non-infective, obliately, intracellular form
microbes enter body through scrapes or cuts
can spread to lymphatic system and cause proctitis
if teen girls have it, it can increase risk for getting cervical cancer
dx by detecting chlamydia DNA by PCR
treat with antimicrobial drugs
prevent by abstinence or by having a monogamy