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Non-Insulin Therapy (Mechanism of Action (proliferator-activated receptor…
Non-Insulin Therapy
Mechanism of Action
proliferator-activated receptor-gamma
Leads to increased
transcription of proteins
Agonist to receptors called peroxisome
Augmentation of the post-receptor actions of insulin
improved insulin sensitivity
and B-cell function
Contraindications
Type 1 DM
History of osteoporosis
Hypersensitivity to pioglitazone
History of bladder cancer
History of congestive heart failure
Side effect
Precipitation of congestive heart failure
Bladder cancer
Fluid retention
Distal long-bone fractures
Indications
High risk for hypoglycaemia
History of severe hypoglycaemia
history of a MI and stroke
Patients with side-effects with metformin
Dosage
After 1-3 months/PRN
30mg
Maximum dose
45mg/daily
Starting dose
15mg/daily
Drug name
Rosiglitazone
Pioglitazone
Class
Thiazolidinediones