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Non-Insulin Therapy (Contraindications (Type 1 diabetes, Hypersensitivity…
Non-Insulin Therapy
Contraindications
Type 1 diabetes
Hypersensitivity to sulfonylureas
GI tract disorders
Pregnancy and lactation
Liver disease because of hepatic metabolism
Side effect
Weight gain
Constipation
Hypoglycaemia
Nausea
Mechanism of Action
KATP channels on pancreatic beta cells depolarization
Calcium influx and exocytosis of stored insulin
Insulin secretagogue that binds to SUR1A
Gliclazide modified-release is a sulphonylurea
Indications
when rapid control of hyperglycaemia is desirable
Not maintaining desirable
glycaemic targets.
When metformin is contraindicated
Intolerable side-effects with
metformin
Drug name
Glyburide
Glipizide
Gliclazide modified-release
Dosage
Depending fasting glucose levels
30 to 60mg/ 1-4 weeks
maximum dose
120mg/daily
Starting dose
30-60 mg/day
Class
Sulfonylurea