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PIOGLITAZONE (CONTRA INDICATIONS (Liver disease, History of heart falure,…
PIOGLITAZONE
CONTRA INDICATIONS
Liver disease
History of heart falure
Breastfeeding
Do not give with insulin
Pregnancy
ADVERSE EFFECTS
bladder cancer
Fracture especially on women
Heart failure
hypoglycaemia
MECHANISM OF ACTION
Increase glucose intake by muscle and adipose tissues
Decrease glucose production by the liver
Reduce tissue resistance to insulin
INDICATION
They are not supposed to be used with insulin
They can be used with metformin or sulphonylures in lowering blood glucose
EFFECT ON THE KIDNEYS
Cause renal impairment
Causes death
DOSE
Give 15 or 30 mg once a day after a meal
STORAGE
Must be stores at a temperature of 20 -25 degrees