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Non-Insulin Therapy (Side effect (Angioedema, Headache, risk for…
Non-Insulin Therapy
Side effect
Angioedema
Headache
risk for pancreatitis
Upper Respiratory Infection
Risk of heart failure
Contraindications
Pancreatic cancer
liver disease
Pancreatitis
History of Pancreatitis
Drug name
Sitagliptin
Vildagliptin
Saxagliptin
Dosage
Sitagliptin
100 mg daily
Vildagliptin
50 mg/Bd
Saxagliptin
5 mg daily
Indications
Approved
for addition as third-line therapy
Risk of hypoglycaemia
Combinaed with metformin as second-line agents
Mechanism of Action
Therapeutically
raising circulating GLP-1 levels
Inhibits the degradation of endogenous GLP-1
Class
DPP-4-inhibitors