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DPP-4-INHIBITORS (Side effects (Small absolute risk for pancreatitis,…
DPP-4-INHIBITORS
Side effects
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Gastrointestinal problems including nausea, diarrhea and stomach pain
Flu-like symptoms headache, runny nose, sore throat.
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Dose
Saxagliptin: >50 ml/min- 5 mg daily, 30-50 ml/min- 2.5 mg daily, <30 ml/min- 2.5 mg daily
Sitagliptin: >50 ml/min- 100 mg daily, 30-50 ml/min- 50 mg daily,<30 ml/min- 25 mg daily
Vildagliptin: >50 ml/min- 50 mg twice a day, 30-50 ml/min- 50 mg daily, <30 ml/min- 25 mg daily
Storage condition
Upon arrival, store at 4°C
For long-term of more than 2 weeks, store at –20°C
Mode of action
Are inhibiting the degradation of endogenous GLP-1, therapeutically increasing circulating GLP-1 levels
Definition
Are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4) used to treat diabetes mellitus type 2.