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Non-Insulin Therapy (Side effect (Nausea, Vomiting, Diarrhea, Cramping,…
Non-Insulin Therapy
Side effect
Nausea
Vomiting
Diarrhea
Cramping
Flatulence
Bloating
Indications
In case Metformin resistance
Monothrapy in mild cases
Type 2 Diabetes Melitus
Obese patients with type 2 DM
Contraindications
Individuals who don't wish to lose weight
Patients with irritable bowel syndrome
History of metformin intolerance
Chronic gastrointestinal disorders
Mechanism of Action
Decrease intestinal absorption glucose
Anti-oxidative properties on endothelial cells
Decrease hepatic glucose production
Dosage
Standard dose
1000 – 2550mg/day in 2-3 divided doses.
cardiovascular
benefit in obese patients
850 mg TDS
Starting dose
500mg/daily
Drug name
Metfomin ER
Metformin
Class
Biguanide