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Migraine (Signs and Symptoms (headache that begins as a dull ache and…

- - - - Selective agonist for serotonin 5-HT1E and 5-HT1D receptors in the cranial arteries causing vasoconstriction and reducing inflammation associated with neuronal transmission of migraine
    - - Fatigue
      - Drowsiness
      - Vertigo
      - Dizziness
      - Hot and cold flashes
    - - Migraine relief
  - - - Anaphylaxis
      - Injection site reaction
      - Antibody development
      - Skin Rash
      - Angioedema
    - - Migraine prophylaxis
    - - Humanized monoclonal antibody that binds to calcitonin gene related peptide ligand, blocking binding to the receptor
  - - - Skin rash
      - Nausea and vomiting
      - Anemia
      - Liver damage
      - Nephrotoxicty
    - - Analgesic to relieve pain associated with migraine
  - - - Acetaminophen: activation of serotonergic inhibitory pathways
      - Aspirin: inhibits COX-1 and COX-2 enzymes through acetylation decreasing the formation of thromboxane A2 via acetylation of platelet cyclooxygenase. This inhibits platelet aggregation giving an antipyretic, analgesic, and anti-inflammatory effect.
      - Caffeine: increases levels of 3’5’ cAMP by inhibiting phosphodiasterase
    - - Pain relief in migraine
    - - Skin rash
      - Chest pain
      - Nephrotoxicity (overuse)
      - GI ulcer
      - Bleeding
  - - - Nasal discharge
      - Hypertensive crisis
      - Dizziness
      - Blindness and/or vision impairment
      - Nausea and vomiting
    - - antagonizes the vasodilation in the cranial vessels that causes migraine , therefore inhibiting migraines
    - - Sumatriptan causes constriction of the cranial vessels and inhibits pro inflammatory neuropeptide release by agonist activation the 5-hydroxytriptamine 1B or 1D receptor on the intracranial blood vessels and sensory nerves of the trigeminal system.