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Hypothyroidism (Risk Factors (Acquired (Goitrogenic Agents (Antithyroid…
Hypothyroidism
Risk Factors
Congential
Exposure to Iodine Substances
Antithyroid Drugs
propylthiouracil
methimazole
Povidone-iodine (Disinfectant)
Delayed Maturation of Hepatic System
Unable to Conjugate bilirubin
Acquired
thyroidectomy
Ablation from radiation
Goitrogenic Agents
Lithium
Antithyroid drugs
Propylthiouracil
Methimazole
Causes
Congenital
Lack of Thyroid Gland
Abnormal biosynthesis of Thyroid Hormone
Deficient TSH Secretion
Acquired
Destruction/Dysfunction of Thyroid
Thyroidectomy
(Secondary) Impaired Pituitary Function
(Tertiary) Hypothalamic Dysfunction
Hashimoto thyroiditis
Autoimmune Disorder
Primarily in Females
Gland destroyed
Subacute thyroiditis (Postpartum)
Clinical Manifestations
Congenital
Cretinism
Enlarged Tongue
Feeding Difficulties
Respiratory Difficulties
Hoarse Cry
Somnolence
Enlarged Abdomen
Umbilical Hernia
Slugishness
Prolonged jaundice
Acquired
Hypometabolic State
Gradual onset of weakness and fatigue
Weight gain
No Appetite
Cold Intolerance
Myxedema
Collects in Connective Tissues
Head/Face
Enlarged Tongue
Hoarse Voice
Inner Ear
Conductive Deafness
Any Serous Cavity
Impaired Muscle Function
Stiffness
Cramps
Pain
Complications
Congential
Cretinism
Poor Psychomotor/Mental Development
Acquired
Goiter
Myxedematous Coma
Coma
Hypothermia
CV Collapse
Hypoventilation
Severe Metabolic Disorders
Hyponatremia
Hypoglycemia
Lactic Acidosis
Lab/Diagnostics
Congenital
Screening (first 2 days of life)
Test T4 & TSH
Acquired
Hx
Physical Exam
Lab Tests
T4/TSH Serum Levels
Antithyroid Antibodies
Collaborative Treatments
Congenital
Hormone Replacement/T4 Supplements (first 6 weeks of life)
Acquired
Replacement Therapy
Synthetic T3
Synthetic T4 (most common)
Block Hormone Synthesis= Hypothyroidism w/ Goiter
