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anti-fungal drugs (AZOLE ANTIFUNGAL (fluconazole (Pregnancy - C/D, SE -…
anti-fungal drugs
POLYENES
amphoterine
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SIDE EFFECT/AR - fever, chills, shaking, flushing, loss of appetite, dizziness, nausea, and vomiting
highly toxic and can cause nephrotoxicity and electrolyte imbalance specifically hypokalemia, and hypomagnesemia
MONITORING - urine output, BUN, serum creatinine, complete blood count
nystatin
SIDE EFFECT - diarrhea, nausea, vomiting, dyspepsia
AR - rash, pruritus, urticaria, hyperglycemia
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AZOLE ANTIFUNGAL
ketoconazole, Itraconazole, posaconazole, voriconazole
Azole inhibit cytochrome p450 in fungal cells, interfering with the formation of ergosterol. because ergosterol is major sterol in the fungal cell membrane, cell permeability, and leakage are increased
fluconazole
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SE - nausea, vomiting, diarrhea, abdominal pain, rash, headache, hypokalemia
AR - elevated liver transmainases, hepatic and renal failure, fatal cardiac arrhythmias, toxic epidermal necrolysis
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ECHINOCANDINS
ACTION - inhibit biosynthesis of essential components of the fungal cell wall, which interfere with growth and reproduction of CANDIDA and ASPERGILLUS species
anidulafungin, caspofungin, micafungin