anti-fungal drugs

POLYENES

AZOLE ANTIFUNGAL

ANTIMETABOLIC

MISCELLANEOUS

ECHINOCANDINS

amphoterine

nystatin

ketoconazole, Itraconazole, posaconazole, voriconazole

Azole inhibit cytochrome p450 in fungal cells, interfering with the formation of ergosterol. because ergosterol is major sterol in the fungal cell membrane, cell permeability, and leakage are increased

fluconazole

Flucytosine - disrupts DNA nd RNA synthesis

ACTION - inhibit biosynthesis of essential components of the fungal cell wall, which interfere with growth and reproduction of CANDIDA and ASPERGILLUS species

anidulafungin, caspofungin, micafungin

Griseofulvin

PREGANANCY - C

highly protein bound drug

SIDE EFFECT/AR - fever, chills, shaking, flushing, loss of appetite, dizziness, nausea, and vomiting

highly toxic and can cause nephrotoxicity and electrolyte imbalance specifically hypokalemia, and hypomagnesemia

MONITORING - urine output, BUN, serum creatinine, complete blood count

SIDE EFFECT - diarrhea, nausea, vomiting, dyspepsia

AR - rash, pruritus, urticaria, hyperglycemia

treat candida infection pregnancy - C

Pregnancy - C/D

SE - nausea, vomiting, diarrhea, abdominal pain, rash, headache, hypokalemia

AR - elevated liver transmainases, hepatic and renal failure, fatal cardiac arrhythmias, toxic epidermal necrolysis