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Chapter 18 Lecture 5 (Type IV (Delayed or Cell-Mediated) Hypersensitivity,…

- - - - Grafted T cells attack all of the recipient’s tissues
      - End up with destructive lesions in the skin and intestine
    - - Grafted T cells attack the host’s
  - - - The more closely the donor and recipient are related, the smaller the difference in their MHC
      - Preferable that grafts are donated by a parent or sibling when identical sibling not available
      - Tissue typing used to match donor and recipient
    - - Attempts are made to match donor and recipient as closely by the means of tissue typing
      - Examine white cells of graft recipients to determine what MHC proteins they have
      - When donor organ becomes available it too, is typed and if it is closely matching the less intense the rejection process and the great the chance of successful grafting
      - A match of 50% or less of the MHC proteins is usually acceptable for most organs.
  - - - Glucocorticoids
      - Cytotoxic drugs
      - Cyclosporine
      - Lymphocyte-depleting therapies