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C. Diff (Etiology/Pathophys (Pathologic CDI (Disruption in bowl flora or…
C. Diff
Etiology/Pathophys
Gram positive
Spore forming
Colonizes in large intestine
Fecal-oral transmission
Pathologic CDI
Disruption in bowl flora or inadequate immune response
Toxin A and Toxin B cause symptoms
Clinical Presentation
Symptoms
Watery, non-bloody diarrhea
Abdominal discomfort
Toxic megacolon (severe/fulminant disease)
Diagnosis
C. Diff organisms in stool
Pseudomembranous colitis visualized during endoscopy
Classification
Non-severe
WBC </= 15,000 cells/mm3
SCr <1.5 mg/dL
Severe
WBC >15,000 cells/mm3
SCr >1.5 mg/dL
Fulminant (severe w/sudden onset)
Hypotension or shock
Ileus
Megacolon
Lab testing
Nucleic acid amplification tests (NAAT)
PCR-based toxin testing
Epidemiology
Most common in hospitals and among elterly
Tied to abx use (disrupts gut flora)
Risk factors
Healthcare exposure
Tube feeding
Chemotherapy
Gastric surgery
Treatment
Non-pharm/supportive care
Fluid/electrolyte replacement
Cessation of abx